Ischemic preconditioning reduces hemodynamic response during metaboreflex activation
نویسندگان
چکیده
منابع مشابه
Ischemic preconditioning reduces hemodynamic response during metaboreflex activation.
Ischemic preconditioning (IP) has been shown to improve exercise performance and to delay fatigue. However, the precise mechanisms through which IP operates remain elusive. It has been hypothesized that IP lowers the sensation of fatigue by reducing the discharge of group III and IV nerve endings, which also regulate hemodynamics during the metaboreflex. We hypothesized that IP reduces the bloo...
متن کاملImpaired central hemodynamic response and exaggerated vasoconstriction during muscle metaboreflex activation in heart failure patients.
The muscle metaboreflex is enhanced in chronic heart failure (CHF) patients, and this fact has been associated with the early fatigue shown by these patients in response to exercise. In animal studies of CHF, it was found that the limited capacity to enhance ventricular performance is responsible for a functional shift from a cardiac output to a systemic vascular resistance (SVR) increase in th...
متن کاملIschemic Preconditioning During Coronary
Background Brief episodes of ischemia render the heart more resistant to subsequent ischemia; this phenomenon has been called ischemic preconditioning. In some animal species, myocardial preconditioning appears to be due to activation of ATP-sensitive K' (KATP) channels. The role played by KATP channels in preconditioning in humans remains unknown. The aim of this study was to establish whether...
متن کاملLymphocyte cell kinase activation mediates neuroprotection during ischemic preconditioning.
The molecular mechanisms underlying preconditioning (PC), a powerful endogenous neuroprotective phenomenon, remain to be fully elucidated. Once identified, these endogenous mechanisms could be manipulated for therapeutic gain. We investigated whether lymphocyte cell kinase (Lck), a member of the Src kinases family, mediates PC. We used both in vitro primary cortical neurons and in vivo mouse ce...
متن کاملMicroRNAs induced during ischemic preconditioning.
BACKGROUND AND PURPOSE MicroRNAs (miRNA) are single-stranded short RNA molecules that regulate gene expression by either degradation or translational repression of mRNA. Although miRNAs control a number of conditions and diseases, few neuroprotective miRNAs have been described. In this study, we investigated neuroprotective miRNAs induced early in ischemic preconditioning. METHODS Ischemic pr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
سال: 2016
ISSN: 0363-6119,1522-1490
DOI: 10.1152/ajpregu.00429.2015